Some mutations of interset and the predicted affect from SIFT and PolyPhen. We want to try introduce these mutations in FoldIt!
PDB:1OG5 = CP2C9 Protein | Mut | SIFT | PolyPhen | Index |
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| CYP2C9 | R150H | tolerated | benign | 76 | CYP2C9 | H251R | deleterious | damaging | 222 | CYP2C9 | E272G | deleterious | benign | 243 | | | | | | Index = foldit numbering in "Show alignment" view
PDB:3TBG = CP2D6 Protein | Mut | SIFT | PolyPhen | Index | CYP2D6 | T107I | tolerated | benign | 77 | CYP2D6 | V136I | deleterious | benign | 106 | CYP2D6 | R296C | tolerated | benign | 266 | CYP2D6 | V338M | deleterious | damaging | 308 | CYP2D6 | S486T | tolerated | benign | 456 | |
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The combinations that we are looking at for CYP2D6 are *17: T107I, R296C, and S486T *29: V136I, R296C, V338M, and S486T |