Mutations

Some mutations of interset and the predicted affect from SIFT and PolyPhen. We want to try introduce these mutations in FoldIt!

PDB:1OG5 = CP2C9
 ProteinMut SIFT PolyPhen Index





 CYP2C9 R150H tolerated benign 76
 CYP2C9 H251R deleterious damaging 222
 CYP2C9 E272G deleterious benign 243
     
Index = foldit numbering in "Show alignment" view

PDB:3TBG = CP2D6
 ProteinMut SIFT PolyPhen Index
 CYP2D6 T107I tolerated benign 77
 CYP2D6 V136I deleterious benign 106
 CYP2D6 R296C tolerated benign 266
 CYP2D6 V338M deleterious damaging 308
 CYP2D6 S486T tolerated benign 456



The combinations that we are looking at for CYP2D6 are

*17: T107I, R296C, and S486T

*29: V136I, R296C, V338M, and S486T

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